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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK5
All Species:
44.24
Human Site:
T17
Identified Species:
69.52
UniProt:
Q00535
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00535
NP_004926.1
292
33304
T17
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
Chimpanzee
Pan troglodytes
XP_001149427
306
35062
V17
I
G
E
G
T
Y
G
V
V
Y
K
A
K
N
R
Rhesus Macaque
Macaca mulatta
XP_001102502
306
34957
V17
I
G
E
G
T
Y
G
V
V
Y
K
A
K
N
R
Dog
Lupus familis
XP_532760
331
37322
T56
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
Cat
Felis silvestris
Mouse
Mus musculus
P49615
292
33270
T17
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
Rat
Rattus norvegicus
Q03114
292
33236
T17
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001129258
292
33321
T17
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
Frog
Xenopus laevis
P51166
292
33320
T17
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
Zebra Danio
Brachydanio rerio
NP_571794
292
33381
T17
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48609
294
33162
T17
I
G
E
G
T
Y
G
T
V
F
K
G
R
N
R
Honey Bee
Apis mellifera
XP_391878
299
34094
T17
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
Nematode Worm
Caenorhab. elegans
NP_499783
292
33044
T17
I
G
E
G
T
Y
G
T
V
F
K
A
R
N
K
Sea Urchin
Strong. purpuratus
XP_001200386
295
33676
T27
T
A
E
R
T
Y
G
T
V
F
K
A
K
N
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
V17
I
G
E
G
T
Y
G
V
V
Y
K
A
L
D
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
V17
I
G
E
G
T
Y
G
V
V
Y
K
A
R
D
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59.1
58.8
86.7
N.A.
99.6
99.3
N.A.
N.A.
97.2
96.9
96.5
N.A.
77.5
81.9
73.6
67.1
Protein Similarity:
100
75.1
75.1
87.9
N.A.
100
99.6
N.A.
N.A.
98.9
98.9
98.9
N.A.
86.7
89.3
86.9
78.9
P-Site Identity:
100
86.6
86.6
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
86.6
100
86.6
80
P-Site Similarity:
100
93.3
93.3
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
93.3
100
100
80
Percent
Protein Identity:
N.A.
57.8
N.A.
56.4
N.A.
N.A.
Protein Similarity:
N.A.
76.8
N.A.
75.5
N.A.
N.A.
P-Site Identity:
N.A.
66.6
N.A.
66.6
N.A.
N.A.
P-Site Similarity:
N.A.
86.6
N.A.
93.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
0
0
0
94
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
14
0
% D
% Glu:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
74
0
0
0
0
0
% F
% Gly:
0
94
0
94
0
0
100
0
0
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
94
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
100
0
74
0
20
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
87
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
0
0
20
0
80
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
7
0
0
0
100
0
0
74
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
27
100
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
100
0
0
0
27
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _